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That's the title that Science magazine is bestowing upon the medication called lenacapavir — a twice yearly injectable that prevents infection by the HIV virus.

The new year begins with a host of promising titles from George Saunders, Julian Barnes, Jennette McCurdy, Karl Ove Knausgaard and more. Here's a look ahead at what's publishing this month.

The U.S. has registered over half a million clinical trials since 2000. Here's a look at the business and ethics of human medical experimentation through the eyes of a volunteer.

On today's news: 60k voices collected opposing seabed mining, Saipan Mayor Camacho is running another 4 year term, & Blues by the Bay 2026.

There is broad support for the protests among Israeli officials, but Palestinians say they hope the Iranian regime stays in place and the protests die down soon.

The FBI is solely leading the inquiry into the killing of Renee Macklin Good by ICE agent Jonathan Ross without help from Minnesota authorities. Legal experts explain why the move is unusual and why joint investigations are the norm.

French President Emmanuel Macron laid out an ambitious plan for a "reimagined, restored and expanded" Louvre. An art critic says Macron is aiming for another success after restoration of Notre Dame.

A bill would tie Guam's minimum wage to the Consumer Price Index, but groups representing businesses say that would drive up prices and further hurt the economy.

U.S. Vice President JD Vance will meet Denmark's foreign minister and his Greenlandic counterpart in Washington on Wednesday to discuss the Arctic island, at the center of a geopolitical storm.

China's trade surplus surged to a record of almost $1.2 trillion in 2025, the government said Wednesday, as exports to other countries made up for slowing shipments to the U.S. under President Donald Trump's onslaught of higher tariffs.